Investigating Tissue Heterogeneity using MRI in Prostate Cancer

Multi-parametric MRI, a promising new technique for grading prostate cancer using MRI, classifies a high number of regions as indeterminate. This is a symptom of the wider problem that clinical usage of MRI in prostate cancer only includes basic techniques and does not directly categorise tissue microstructure. This work provides insight into the microstructure of the prostate using a combination of new tissue models and acquisition schemes. Each is tested with the aim of producing a method that is better at detecting and grading prostate cancer. The first section utilises microstructural diffusion models to better quantify tissue heterogeneity in the prostate. The two models investigated provided more information about the heterogeneous nature of the prostate that ADC and showed significant difference between lesions and normal tissue. The next section looks into combining multi-echo T2 (ME-T2) sequences with quantitative tissue modelling called Luminal Water Imaging (LWI). This work produced an optimal LWI fitting technique and acquisition. Then the ability of LWI to detect the PI-RADS v2.0 score of regions of interest was examined, showing that it was able to differentiate between scores better than ADC. This work also showed that LWI can differentiate between tumour and normal tissue with an AUC of 0.81 (p<0.05) when compared to ADC with an AUC of 0.75 (p<0.05) in this dataset. The next section further improves the acquisitions using larger datasets. It showed that correcting for imperfect pulse refocusing could improve on the performance of LWI in detecting PCa. This work also showed that fewer echoes could be used in the acquisition. Neural networks were then used to detect and grade prostate cancer using the data points from both multiple b-value diffusion and ME-T2 decay curves. The neural network’s ability to distinguish between different PIRADS scores was shown to have an AUC of 0.87 (p<0.05) using 32-echo data

The motivation to express prejudice

Contemporary prejudice research focuses primarily on people who are motivated to respond without prejudice and the ways in which unintentional bias can cause these people to act inconsistent with this motivation. However, some real-world phenomena (e.g., hate speech, hate crimes) and experimental findings (e.g., Plant & Devine, 2001; 2009) suggest that some expressions of prejudice are intentional. These phenomena and findings are difficult to explain solely from the motivations to respond without prejudice. We argue that some people are motivated to express prejudice, and we develop the motivation to express prejudice (MP) scale to measure this motivation. In seven studies involving more than 6,000 participants, we demonstrate that, across scale versions targeted at Black people and gay men, the MP scale has good reliability and convergent, discriminant, and predictive validity. In normative climates that prohibit prejudice, the internal and external motivations to express prejudice are functionally non-independent, but they become more independent when normative climates permit more prejudice toward a target group. People high in the motivation to express prejudice are relatively likely to resist pressure to support programs promoting intergroup contact and vote for political candidates who support oppressive policies. The motivation to express prejudice predicted these outcomes even when controlling for attitudes and the motivations to respond without prejudice. This work encourages contemporary prejudice researchers to broaden the range of samples, target groups, and phenomena that they study, and more generally to consider the intentional aspects of negative intergroup behavior

Breaking the prejudice habit: Mechanisms, timecourse, and longevity

The prejudice habit-breaking intervention (Devine et al., 2012) and its offshoots (e.g., Carnes et al., 2012) have shown promise in effecting long-term change in key outcomes related to intergroup bias, including increases in awareness, concern about discrimination, and, in one study, long-term decreases in implicit bias. This intervention is based on the premise that unintentional bias is like a habit that can be broken with sufficient motivation, awareness, and effort. We conducted replication of the original habit-breaking intervention experiment in a sample more than three times the size of the original (N = 292). We also measured all outcomes every other day for 14 days and measured potential mechanisms for the intervention’s effects. Consistent with previous results, the habit-breaking intervention produced a change in concern that endured two weeks post-intervention. These effects were associated with increased sensitivity to the biases of others and an increased tendency to label biases as wrong. Contrasting with the original work, both control and intervention participants decreased in implicit bias, and the effects of the habit-breaking intervention on awareness declined in the second week of the study. In a subsample recruited two years later, intervention participants were more likely than control participants to object on a public online forum to an essay endorsing racial stereotyping. Our results suggest that the habit-breaking intervention produces enduring changes in peoples’ knowledge of and beliefs about race-related issues, and we argue that these changes are even more important for promoting long-term behavioral change than are changes in implicit bias

MARC-60 and Propulsion System Collaboration Status Meeting

No abstract availabl

Debunking the \u27gaydar\u27 myth

Kids are often told that you can’t judge a book by its cover. Even so, people often believe they can rely on their gut to intuit things about other people. Stereotypes often influence these impressions, whether it’s that a black man is dangerous, a woman won’t be a good leader or a fashionable man is gay

Gender, Steroids, and Fairness in Sport

Eligibility to compete in sport is organised principally around two binary distinctions: ‘clean/doped’ and ‘male/female’. These distinctions are challenged both by steroid users who wish to return to competition following a period of suspension, and trans women athletes who wish to compete in women’s events. Recent empirical work has suggested that steroid users retain an elevated capacity for muscle reacquisition years after they cease to use steroids. I suggest that an analogous worry may arise with respect to certain trans women athletes who wish to compete in women’s events. If sound, this argument would establish an unexpected parallel between eligibility debates surrounding returning dopers and trans women athletes

On-line GIS instruction at the North Carolina State University College of Forest Resources

The College of Forest Resources GIS Research and Teaching Program at North Carolina State University has developed a student directed learning program for GIS applied to Natural Resource Management. Students in the introductory GIS course independently learn elementary spatial analysis over the computing network and apply these concepts in the professional development courses. The core of this two year GIS curriculum design effort is the campus-wide GIS delivery system. This system is a cooperative effort among the NC State Libraries, the Instructional Technology Office, and the College of Forest Resources. The Libraries house and maintain the spatial data and provide assistance to users, the Informational Technology staff provide the delivery of GIS to over 2000 campus computer seats, and the College delivers the formal instruction program and houses the spatial analysis research effort. The instruction program is centered on student laboratories that are offered on the World Wide Web. Students review the material demonstrated in class and practice application of this material in a virtual laboratory environment. Homework submission and return, help sessions, and project presentations are all done electronically. This paper highlights the on-line GIS instruction system, curriculum, laboratory exercises, and student evaluations of this on-going effort